Indiana University
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Frederick Unverzagt, PhD

Dr. Unverzagt has research interests in clinical assessment of memory loss and dementia. He is the principal investigator of an National Institute of Aging-funded observational study of the risk factors for progression of mild cognitive impairment (MCI) in a primary care cohort. He is also the site-PI for the ACTIVE study (Advanced Cognitive Training for Independent Vital Elderly), a multi-center, randomized-controlled trial of the effectiveness of cognitive interventions in helping older adults forestall decline in activities of daily living.

Dr. Unverzagt is co-investigator in large cross-national, community-based studies of the prevalence, incidence, and risk factors for cognitive decline, MCI, and Alzheimer disease in the US, Nigeria, Kenya, Jamaica, and China. He has adapted cognitive and clinical assessment techniques for use in these cross-national studies and developed training programs for their use.

He is also co-investigator for the NIA-funded Indiana Alzheimer Disease Center, one of 32 such research centers in the US. In that capacity, he has been involved in the longitudinal assessment of large families affected with genetically-determined neurodegenerations including: early onset Alzheimer disease, Gerstmann-Sträussler-Scheinker disease (an inherited prion diesase), and multiple system tauopathy with presenile dementia.

Dr. Unverzagt also has interest in studying cognitive dysfunction in breast cancer patients. He has assembled and validated a sensitive battery of tests and adapted these tests for telephone-based administration in a large American Cancer Society study of quality of life in breast cancer survivors.

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